PRP Hair Rejuvenation

Platelet-Rich Plasma (PRP) therapy has shown promise in treating hair loss, particularly androgenetic alopecia (AGA) and alopecia areata (AA). Here are the key findings:

1. Effectiveness in Androgenetic Alopecia (AGA):
   • PRP treatments have been found to significantly increase hair density and hair count. For instance, a study involving 18 participants receiving non-activated PRP showed a clinical improvement in hair count (36 ± 3 hairs) and hair density (65 ± 5 hairs/cm²) three months post-treatment.
   • Another study reported a mean increase of 33.6 hairs in the target area and a mean increase in total hair density of 45.9 hairs/cm² compared with baseline values.
2. Effectiveness in Alopecia Areata (AA):
   • PRP has also been effective in treating AA. In a randomized controlled trial, PRP-treated patients showed significantly more hair regrowth compared to placebo-treated patients.
3. Mechanism of Action:
   • PRP works by releasing growth factors and cytokines that promote cell proliferation, differentiation, and angiogenesis. Key growth factors include platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF), which help extend the anagen phase of hair growth and promote vascularization.
4. Treatment Protocols:
   • The typical PRP treatment involves multiple sessions. Studies suggest that three monthly sessions followed by maintenance sessions every 3-6 months yield the best results.
5. Comparative Effectiveness:
   • PRP has been shown to be more effective than placebo in increasing hair density and hair count. Meta-analyses have confirmed PRP's superiority over placebo in terms of mean change in hair density.